Best 68 quotes in «niche quotes» category

There's plenty of money in any niche where you're scratching a genuine business niche.

The study of stem cell niches in mammalian systems presents an 'arduous endeavor'; in comparison, the fly germarium is relatively easy to manipulate. In the 1990s, H. Lin, A.C. Spradling, and others used of a number of approaches to study Drosophilia GSCs and their niche, including killing specific cells in the germarium with precisely directed lasers; transplantation of cells from the ovary of one fly to another; and genetic perturbations that included the dialing up or down of Hh pathway signaling. The researchers found that following laser ablation of cells surrounding the GSCs - that is killing the niche cells - all the GSCs went on to form eggs, and the system was quickly depleted of its GSC reserve. Moreover, through genetic analyses the researchers identified specific genes required in the niche cells to maintain GSCs within the niche, as would be deduced for a gene that, when disrupted in niche cells, has the same effect as laser ablation of those cells. These studies are credited with providing the first clear experimental evidence of a stem cell niche, as well as defining what genes - what signaling pathways and other cellular activities - are important to the process. Many of the same pathways relevant in other cell types proved relevant to communication between the niche and GSCs, including the Hh pathway. The genes required for suppression of transposon mobilization by the piRNA system also have relevance to the GSC niche; disruption of the piwi gene, for example, can lead to uncontrolled proliferation of GSCs.

We shall best understand the probable course of natural selection by taking the case of a country undergoing some physical change, for instance, of climate. The proportional numbers of its inhabitants would almost immediately undergo a change, and some species might become extinct. We may conclude, from what we have seen of the intimate and complex manner in which the inhabitants of each country are bound together, that any change in the numerical proportions of some of the inhabitants, independently of the change of climate itself, would most seriously affect many of the others. If the country were open on its borders, new forms would certainly immigrate, and this also would seriously disturb the relations of some of the former inhabitants. Let it be remembered how powerful the influence of a single introduced tree or mammal has been shown to be. But in the case of an island, or of a country partly surrounded by barriers, into which new and better adapted forms could not freely enter, we should then have places in the economy of nature which would assuredly be better filled up, if some of the original inhabitants were in some manner modified; for, had the area been open to immigration, these same places would have been seized on by intruders. In such case, every slight modification, which in the course of ages chanced to arise, and which in any way favoured the individuals of any of the species, by better adapting them to their altered conditions, would tend to be preserved; and natural selection would thus have free scope for the work of improvement.

When a man finds this kind of woman, he will go all out for her knowing that she will not be a letdown.

You can change any status quo, stand out, walk by faith and not by sight and things will definitely go well with you.

Whether you try too hard to fit in or you try too hard to stand out, it is of equal consequence: you exhaust your significance.

You have the ability to shine and make a mark in some field. Your job is to find your niche, excel and build a lasting legacy.

American Pie speaks to the loss that we feel. That's why that song has found the niche that it has.

Certainly, jazz has become more of a niche, which is surprising, because it's our music. It's the national music of America.

Education is always very important. Ultrasound is, I think, quite a niche market. We know our customers very well. We listen to a lot of feedback and they're more than happy to tell us their thoughts.

Compelling spectacles are not to reach a niche market, it could be for reaching a niche marketing but on a grand scale. This is for grand marketing.

For a foreigner, L.A. is such a big, wonderful and weird place that, until you find your niche, you feel a little bit discombobulated.

Far from being the smartest possible biological species, we are probably better thought of as the stupidest possible biological species capable of starting a technological civilization - a niche we filled because we got there first, not because we are in any sense optimally adapted to it.

Donald Trump, as a businessman, he's not much of a builder and he's not much of dealmaker and he certainly isn't very good at making expenses line up with income. But he is a marketing genius. He must have seen an empty market niche that no one but him filled.

In the '90s, you couldn't say the word 'nerd' to someone when pitching a show. They would have considered that too niche and wouldn't have listened.

I couldn't see myself filling some definite niche in what is called a career. This was all misty.

I'm not that clued into what people are that touchy about and how many of them there are and how niche these niches are.

I don't do anything for the money. I don't need to. I could have retired after White Zombie and been just fine. Money doesn't matter. But there is still a good living to be made, even in the niche. The funny thing is, as time goes on, the niche stuff gets bigger and bigger.

In fame's temple there is always a niche to be found for rich dunces, importunate scoundrels, or successful butchers of the human race.

I prefer to shoot the arrow, then paint the target around it. You make the niches in which you finally reside.

OLD: Be No.1 or No.2 in Your Market. NEW: Find a Niche, Create Something New.

I went looking for dresses and realized there was a niche I could fill in the wedding dress market.

People who have come from nothing and started their own business or opened up a whole new niche in a particular industry, they truly inspire me.

Showtunes might be able to come back into pop music, which is something we haven't seen since the 50s and 60s. Everything is related to everything else because we're in such a niche industry.

One of the main pitfalls of any theoretically "niche" show is that you spend too much time on the "niche" and not enough time on the "show.

It's true that compared with the scene when Unix started, today the ecological niches are fairly full, and fresh new OS ideas are harder to come by, or at least to propagate.

The key to competing and surviving against Wal-Mart is to focus your business into a niche or pocket where you can leverage your strengths in the local marketplace.

Private equity capital in each of those markets Europe and Asia - while those markets have very different characteristics - fills a niche where either strategic investors or the public markets don't go, or don't want to go for some particular reason. I think that's going to continue to be the case going forward.

The question that will decide our destiny is not whether we shall expand into space. It is: shall we be one species or a million? A million species will not exhaust the ecological niches that are awaiting the arrival of intelligence.

Then I realized my early work did have something special that audiences adored apart from what I humbly thought about them. They occupy a distinguished niche in Italian film history and probably always will.

There are a lot of authors in the world, so it's difficult to find a unique niche to present your take on things. That is always a challenge for any author.

You never really know if it's going to happen or not do you but the vision was always for [Karen Walker] to be a global niche luxury product.

We are in niche consumption mode, but 'niche' doesn't mean 'small' anymore. Niche can mean focused, and particularly with the Web, which is a global audience you can have something niche and still get 10 to 15 million views.

Accept responsibilities for all your actions. Learn from your past and your mistakes.

A confident woman knows her worth and so doesn’t fret when her man is highly placed or is often found amidst other women in the course of his business or assignment.

A matured woman is therefore a responsible woman irrespective of her age, status and qualification.

The thing the ecologically illiterate don't realize about an ecosystem is that it's a system. A system! A system maintains a certain fluid stability that can be destroyed by a misstep in just one niche.

We remain unconvinced that consumer appetite for mobile TV services exists outside of niche segments.

An intelligent woman is a goldmine! She has the ability to learn, reason and understand things better and faster than her contemporaries. She is competent, alert and can reason out stuffs easily.

A responsible woman guides, controls (albeit subtly), directs with superior knowledge that is higher than that of her contemporaries!

A responsible woman doesn’t see opportunities and needs and look the other way pretending not to see them rather she gets to work to ensure things are done properly and her man succeeds in his endeavours.

Be positive at all times! Leave out the negatives.

Be the master of your craft in black and white, kick asses and run wild with it locally and globally.

A woman can tolerate delays knowing they are not denials; she is diligent, and composed. She is not easily irritated like love; she endures all things, beans all things and can be stretched to any limit.

Don`t turn around in circles for making circles do not equate making progress.

Carve-out a niche, craft a personal pitch, push-out content and your brand is enriched.

Concerning Personal Branding: For the success of your ‪brand‬ you must know and understand i. your target market and ii. your niche. The two are not the same.

Decide to be rich! Hate poverty strong.

Don`t descend to the lowest ebb.

Don't just float through life; don't just agree to anything and everything, have a course you are known for at all times.